Alkaline phosphatase (AP)
Alanine aminotransferase (ALT)

Both AP and ALT are usually elevated in untreated hyperadrenocorticism. AP is elevated in dogs because of induction of a steroid induced isoenzyme and ALT is elevated because of a “steroid hepatopathy”. By measuring these enzymes, it is possible to assess improvements in liver pathology and circulating steroid concentrations. The Vetoryl® datasheet recommends that dogs should be monitored at regular intervals for primary hepatic disease.

Urea
Creatinine
Phosphorus

The measurement of urea, creatinine and phosphorus will assist in the identification of renal disease (and iatrogenic hypoadrenocorticism). Renal dysfunction is not uncommon in geriatric dogs. The Vetoryl® datasheet recommends that dogs should be monitored at regular intervals for renal disease and that the product should not be used in dogs with renal insufficiency.

Total protein
Albumin
Globulin (calculated)

The measurement of proteins aids in the assessment of hydration status in dogs that may be polydipsic. Albumin and globulin measurement can help identify late stage (protein-losing) glomerulopathies and inflammatory disorders that can affect dogs with hyperadrenocorticism

Cholesterol

Cholesterol is commonly elevated in dogs with untreated hyperadrenocorticism. Measurement during therapeutic monitoring provides information on whether deranged lipid metabolism has been corrected.

Glucose

Diabetes mellitus is not uncommon in dogs with both untreated and treated hyperadrenocorticism. The Vetoryl datasheet recommends that dogs are monitored at regular intervals for diabetes mellitus.