Acetylcholine Receptor Antibodies (ACRAB)

Acquired canine myasthenia gravis (cMG) is an autoimmune disease of neuromuscular transmission caused by autoantibodies directed against the acetylcholine receptors at the neuromuscular junction. cMG can occur as two forms, focal and generalised. In focal MG dogs usually present with megaoesophagus as weakness affects the oesophageal, pharyngeal and facial muscles. In generalised cMG there is widespread skeletal muscle weakness which is made worse by exercise. ACRABs may only be used to diagnose the acquired form of the disease.

Positive serum titre for ACRABs is highly suggestive of acquired cMG.

A 1mL serum sample is required.